Calcium response in osteocytic networks under steady and oscillatory fluid flow
نویسندگان
چکیده
منابع مشابه
Spatiotemporal properties of intracellular calcium signaling in osteocytic and osteoblastic cell networks under fluid flow.
Mechanical stimuli can trigger intracellular calcium (Ca(2+)) responses in osteocytes and osteoblasts. Successful construction of bone cell networks necessitates more elaborate and systematic analysis for the spatiotemporal properties of Ca(2+) signaling in the networks. In the present study, an unsupervised algorithm based on independent component analysis (ICA) was employed to extract the Ca(...
متن کاملOsteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow.
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular activities of other bone cells. Little is known about how osteocytic networks respond to physiological mechanical stimuli. In this study, we compared the mechanical sensitivity of osteocytic and osteoblastic networks under physiological-related f...
متن کاملNumerical treatment for nonlinear steady flow of a third grade fluid in a porous half space by neural networks optimized
In this paper, steady flow of a third-grade fluid in a porous half space has been considered. This problem is a nonlinear two-point boundary value problem (BVP) on semi-infinite interval. The solution for this problem is given by a numerical method based on the feed-forward artificial neural network model using radial basis activation functions trained with an interior point method. ...
متن کاملFluid Flow Induced Calcium Response in Bone Cell Network.
In our previous work, bone cell networks with controlled spacing and functional intercellular gap junctions had been successfully established by using microcontact printing and self assembled monolayers technologies [Guo, X. E., E. Takai, X. Jiang, Q. Xu, G. M. Whitesides, J. T. Yardley, C. T. Hung, E. M. Chow, T. Hantschel, and K. D. Costa. Mol. Cell. Biomech. 3:95-107, 2006]. The present stud...
متن کاملPseudo Steady State Gas Flow in Tight Reservoir under Dual Mechanism Flow
Gas reservoirs with low permeability (k<0.1 mD) are among the unconventional reservoirs and are commonly termed as "Tight Gas Reservoirs". In conventional gas reservoirs that have high permeability, the flow of gas is basically controlled by the reservoir permeability and it is calculated using the Darcy equation. In these reservoirs, gas flow due to gas diffusion is ignored compared to Dar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone
سال: 2012
ISSN: 8756-3282
DOI: 10.1016/j.bone.2012.05.021